Laboratory of Cell activity regulation
Current research activities of the laboratory are concentrated upon investigation of the dysfunctions in lipid modification and signal transduction rapid and reversible mechanisms in human blood lymphocyte plasma membranes at diverse types of cancer. Particularly, we have shown that changes in the processes of plasma membrane lipids short term acylation by exogenous arachidonic acid as well as in the activities of some enzyme systems of phospholipid modification are common characteristics for all the studied types of leukemia. Elucidated mechanisms can lead to the discovery of novel targets and modes for the personalized treatment of cancers.
The research team
Prof. Yuri Tadevosyan, DrSc — Head of Laboratory
Tamara Batikyan, PhD — Senior Researcher
Rafik Ghazaryan, PhD — Senior Researcher
Gohar Hakobyan, PhD — Researcher
Mihran Lazyan — Junior Researcher
Tigran Torgomyan — Junior Researcher
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Projects
- MES RA #0431(2008-2010): «Investigation of lipid modification and signal transduction mechanisms in blood lymphocytes at breast cancer» (PI: Yuri Tadevosyan);
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CRDF N AB1-2308-YE-02 (2002-2004): «Regulation of PKC recruitment to the T cell immunological synapse and its activation by lipid second messengers» (PI: Yuri Tadevosyan).
Partners Abroad
- International Scientific Research Center, Department of Biochemistry, Szeged, Hungary: “Lipid second messengers rapid generation in ConA-stimulated lymphocytes”
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La Jolla Institute for Allergy and Immunology, Laboratory of Cell Biology, San Diego, USA: “Regulation of PKC recruitment to the T cell immunological synapse and its activation by lipid second messengers.”
Patents:
“Mode for diagnostics and/or state value of leukemia’s.”
(in progress, submission number AM20080182, 2008)
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Partners in Armenia
Partners in Armenia:
- Yerevan State University, Department of Biophysics: “Regulation of cell signaling and activity of lipid modification membrane-bound enzyme systems by steroid hormones.”
- Yerevan State Medical University, Department of Pharmacology: “Cell Signaling and lipid modification enzyme systems at hypokinesia.”
- Yerevan State Medical University, Scientific Research Center: “The influence of external electrostatic fields on the activities of lipid modification membrane bound enzyme systems.”
- Yerevan Hematological Center: “Cell signaling, lipid modification enzyme systems and lipid second messenger generation in blood lymphocytes at the diverse forms of leukemia.”
- Yerevan State Medical University, Department of Normal Physiology: “Plasma membrane signal transduction and lipid modification enzyme systems in conditions of cell stimulation by parathyroid hormone.”
- Yerevan State Medical University, Department of Biochemistry: “Plasma membrane signal transduction systems and activities of lipid modification membrane-bound enzymes in conditions of opioid receptor stimulation and diabetes.”
- Yerevan Scientific-Industrial Аssociation “Nairit”: “Investigation of lipids fatty acid content modification and lipid second messenger generation mechanisms in blood lymphocytes.”
- Yerevan National Center of Tumors after V.A.Fanarjian: “Cell Signaling, lipid modification enzyme systems and lipid second messengers generation in blood lymphocytes at the diverse forms of solid tumors.”
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