Dr. rer. nat. Henry Loffler-Wirth
Molecular biology is presently flooded by terabytes of high-throughput data generated by newest generation sequencing and microarrays as well as by protein shotgun
experiments which challenge tasks such as dimension reduction, data compression, visual perception, data integration and extraction of biological information.
Information technology and, particularly, machine learning enable recognizing complex patterns and make intelligent decisions based on such large-scale data sets.
Application of these techniques for analyzing molecular-biological data requires adaptation of statistical methods, e.g. for class discovery and feature selection,
consideration of previous knowledge for interpretation in the context of biological function and also easy-to handle tools for direct use by biologists and
non-informaticians which allow to generate hypotheses about functional relationships directly from the data.
Current work and scientific background:
Research Fellow - Algorithms for life sciences, Analysis of OMICs Data, Artificial Neural Networks.
Diploma in Computer Science (Dipl.-Inf.):
Modellierung eines zellularen Automaten auf Basis dendritischer Zellen und Anwendung in der Mustererkennung.
Technical University of Chemnitz 2008
PhD in Bioinformatics (Dr. rer. nat.):
Analysis of large-scale molecular biological data using self-organizing maps.
University of Leipzig 2012.
- L. Rohani, C. Fabian, H. Holland, Y. Naaldijk, R. Dressel, H. Loffler-Wirth, H. Binder, A. Arnold, A. Stolzing. Generation of human induced
pluripotent stem cells using non-synthetic mRNA. Stem Cell Res. 2016. 16: 662-72.
- H. Loeffler-Wirth, E. Willscher, P. Ahnert, K. Wirkner, C. Engel, M. Loeffler, H. Binder. Novel Anthropometry Based on 3D-Bodyscans Applied
to a Large Population Based Cohort. PLoS One. 2016. 11: e0159887.
- K. Keysselt, T. Kreutzmann, K. Rother, C. Kerner, K. Krohn, J. Przybilla, P. Buske, H. Loffler-Wirth, M. Loeffler, J. Galle, G. Aust.
Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency. Oncogene. 2016.
- T. Gerber, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. Schadendorf, M. Schartl, U. Anderegg, G. Camp, B. Treutlein, H. Binder, M. Kunz.
Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq. Oncotarget. 2016.
- A. Arakelyan, L. Nersisyan, M. Petrek, H. Loeffler-Wirth, H. Binder. Cartography of Pathway Signal Perturbations Identifies Distinct
Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet. 2016. 7: 79.